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. Author manuscript; available in PMC: 2017 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2016 Mar 17;36(5):810–816. doi: 10.1161/ATVBAHA.115.306871

A. Two representative micrographs of coronary plaque rupture are shown. The lesions show marked lumen stenosis (>80%). At high magnification, the top lesion shows distinct disruption (arrowhead) associated with a thrombus. The bottom lesion shows an intimal split (arrowhead) in which some red blood cells are contained.

B. The surface of a fibrotic plaque was partially eroded or defective (arrows), covered by blood cells. The left panel shows HE staining and the right panel shows EVG staining.

C. Typical mural thrombi are shown in three coronary lesions. The coronary lumen was partially filled with a thrombus (arrows) which contains fibrin and blood cells (top and bottom panels). Please note that opposite to the thrombus, the lesion surface is eroded (arrowheads) and calcification is seen at the bottom of the lesions (top panels). Foam cells are accumulated beneath the thin cap of a vulnerable plaque (arrowheads) (bottom right).

A. Two representative micrographs of coronary plaque rupture are shown. The lesions show marked lumen stenosis (>80%). At high magnification, the top lesion shows distinct disruption (arrowhead) associated with a thrombus. The bottom lesion shows an intimal split (arrowhead) in which some red blood cells are contained.

B. The surface of a fibrotic plaque was partially eroded or defective (arrows), covered by blood cells. The left panel shows HE staining and the right panel shows EVG staining.

C. Typical mural thrombi are shown in three coronary lesions. The coronary lumen was partially filled with a thrombus (arrows) which contains fibrin and blood cells (top and bottom panels). Please note that opposite to the thrombus, the lesion surface is eroded (arrowheads) and calcification is seen at the bottom of the lesions (top panels). Foam cells are accumulated beneath the thin cap of a vulnerable plaque (arrowheads) (bottom right).