Table2.
Summary of the effects of gene polymorphisms on the risk of various cancers
| Cancer type | SNP polymorphism | Outcome | Additional comments | Reference |
| BC | Rs2241766 (ADIPOQ) | OR=0.61 (0.46-0.80) | TG genotype significantly associated with reduced BC risk | 77 |
| Rs1501299 (ADIPOQ) | OR=1.80 (1.14-2.85) HR=1.23 (1.059-1.43) | GG genotype significantly associated with higher BC risk | 77,78 | |
| Rs7539542 (ADIPOR1) | OR=0.51 (0.28-0.92) | CC significantly associated with reduced BC risk | 77 | |
| CRC | Rs2241766 (ADIPOQ) | OR=1.433 (1.014-1.985) | TG and GG carriers significantly associated with higher CRC risk | 75 |
| Rs1342387 (ADIPOR1) | OR=0.74 (0.57-0.97) for Ou et al study; OR=0.82 (0.72-0.94) for Ye et al study (homozygous model) | G/A and CT/TT genotypes significantly associated with reduced CRC risk | 90,92 | |
| Rs1501299 (ADIPOQ) | OR=0.723 (0.531-0.902) | GT and TT genotypes significantly associated with reduced risk of CRC | 75 | |
| EC | Rs1063539 (ADIPOQ) | OR=0.39 (0.17-0.90) | CC and CG genotypes significantly associated with decreased risk | 102 |
| GC | Rs266729 (ADIPOQ) | HR=0.74 (0.56-0.97); P=0.032 | GG/CG genotypes associated with significantly lower GC mortality | 108 |
| Rs16861205 (ADIPOQ) | OR=0.61 (0.39-0.94) | Genotypes with minor allele A associated with decreased gastric cardia cancer risk | 109 | |
| Rs10773989 (ADIPOR2) | OR=0.70 (0.52-0.93) | Genotypes with minor allele C associated with decreased risk of gastric cardia cancer | 109 | |
| Rs1044471 (ADIPOR2) | OR=0.70 (0.52-0.95) | Genotypes with minor allele T associated with decreased risk of gastric cardia cancer | 109 | |
| Rs16861205 (ADIPOQ) | OR=1.82 (1.15-2.89) | Genotypes with minor allele A associated with increased risk of gastric body cancer | 109 | |
| PC | Rs1501299 (ADIPOQ) | OR=1.86 (1.03-3.38) | CC genotypes associated with increased PC risk compared to AA genotypes | 120 |
| HC | Rs1501299 (ADIPOQ) | OR=4.33 (2.07-9.05); P<0.005 | GG genotypes associated with increased risk of HCC compared to TT genotypes | 126 |
| RC | Rs182052 (ADIPOQ) | Adjusted OR=1.36 (1.07-1.74) | AA genotypes associated with increased risk of RCC compared to GG | 131 |
| PrC | Rs266729 (ADIPOQ) | P=0.049 | Rare genotypes associated with increased risk | 139 |
| Rs182052 (ADIPOQ) | P=0.04 | Rare genotypes associated with increased risk | 139 | |
| Rs822391 (ADIPOQ) | P=0.04 | Rare C allele associated with decreased risk | 139 | |
| Rs2082940 (ADIPOQ) | P=0.006 | CT and TT genotypes associated with reduced risk | 139 | |
| LC | Rs266730 (APN gene promoter) | P<0.05 | G>A associated with NSCLC risk | 146 |
| Rs2241766 (ADIPOQ) | P=0.012 | TT genotype more prevalent in NSCLC patients than controls | 147 |