Table 3.

Association of cardiovascular disease outcomes with SNPs in the PRCP and KLKB1 genes controlling for age, weight, and gender.

Outcome	PRCP						KLKB1
	rs7104980			rs2298668			rs3733402			rs3087505
	OR	95% CI	P-value	OR	95% CI	P-value	OR	95% CI	P-value	OR	95% CI	P-value
History of diabetes	0.934	(0.723, 1.207)	0.601	0.893	(0.675, 1.183)	0.432	1.054	(0.808, 1.376)	0.696	0.955	(0.689, 1.323)	0.782
History of MI	1.203	(0.998, 1.449)	0.052	1.036	(0.851, 1.263)	0.723	0.958	(0.793, 1.156)	0.652	1.098	(0.874, 1.381)	0.422
History of stroke	1.111	(0.713, 1.732)	0.642	1.013	(0.618, 1.660)	0.959	0.993	(0.623, 1.582)	0.975	0.856	(0.492, 1.487)	0.580
History of angina	0.957	(0.786, 1.166)	0.664	1.068	(0.864, 1.320)	0.541	1.054	(0.859, 1.292)	0.614	0.796	(0.617, 1.029)	0.081
History of angiographic coronary disease	1.062	(0.877, 1.286)	0.535	1.042	(0.848, 1.279)	0.698	0.759	(0.622, 0.927)	0.007*	0.847	(0.670, 1.071)	0.166
History of CABG	1.001	(0.828, 1.211)	0.988	1.064	(0.869, 1.303)	0.548	0.917	(0.756, 1.113)	0.381	1.076	(0.850, 1.361)	0.542
History of intermittent claudication	0.882	(0.636, 1.225)	0.454	1.135	(0.804, 1.604)	0.471	0.994	(0.710, 1.392)	0.971	0.888	(0.579, 1.362)	0.586
History of PTCA	1.211	(1.008, 1.454)	0.041	1.018	(0.836, 1.239)	0.860	1.094	(0.907, 1.319)	0.347	0.970	(0.772, 1.218)	0.792
History of TIA	0.691	(0.425, 1.125)	0.137	0.638	(0.345, 1.181)	0.153	0.847	(0.506, 1.419)	0.528	1.022	(0.542, 1.928)	0.946

SNP rs7104980: G allele compared to no G allele.

SNP rs2298668: G allele compared to no G allele.

SNP rs3733402: G allele compared to no G allele.

SNP rs3087505: A allele compared to no A allele.

*Significant at the Bonferroni corrected P-value correction for assessing four total SNPs = 0.05/4 = 0.0125.