. 2016 Apr 29;3:17. doi: 10.3389/fmed.2016.00017

Table 4.

Model selection for the best fit for the association between SNP rs7104980 (PRCP gene) and SNP rs3733402 (KLKB1 gene) with hypertension and a history of diabetes, cigarette use, or angina.

Covariate(s) added	PRCP – rs7104980					KLKB1 – rs3733402

	History of PTCA					History of angiographic coronary disease

	OR	95% CI	P-value	−2 log L	AIC	OR	95% CI	P-Value	−2 log L	AIC
Baseline^a	1.211	(1.008, 1.454)	0.041	2814.923	2849.357	0.759	(0.622, 0.927)	0.007^*	2605.204	2605.204
Baseline^a + Hypertension	1.209	(1.007, 1.452)	0.042	2812.164	2847.677	0.761	(0.624, 0.930)	0.007^*	2602.004	2604.004
Baseline^a + Hypertension + Hx of diabetes	1.208	(1.006, 1.451)	0.043	2807.581	2847.455	0.760	(0.623, 0.928)	0.007^*	2600.974	2604.974
Baseline^a + Hypertension + Cigarette use	1.214	(1.011, 1.459)	0.038	2804.401	2845.804	0.763	(0.625, 0.931)	0.008^*	2600.346	2604.346
Baseline^a + Hypertension + Hx of angina	1.220	(1.016, 1.467)	0.034	2744.022	2720.286	0.762	(0.623, 0.931)	0.008^*	2573.113	2577.113^b

^aBaseline model includes age, weight, and gender covariates only.

^bLowest AIC value.

*Significant at the Bonferroni corrected P-value for assessing 5 total models = 0.05/5 = 0.01.