Table 4.
Correlations between telomere length and other variables in patients with chronic obstructive pulmonary disease and in controls with normal lung function
| COPD patients | Control patients | |||
|---|---|---|---|---|
| Spearman’s Rho | P value | Spearman’s Rho | P value | |
|
|
|
|||
| Age, y | −0.175 | .042 | −0.29 | 0.0003 |
| Pack-years | 0.02 | 0.82 | −0.09 | 0.25 |
| FEV1, % | 0.03 | 0.75 | 0.04 | 0.66 |
| FEV1, L | 0.08 | 0.38 | 0.03 | 0.71 |
| FVC, L | 0.11 | 0.22 | 0.01 | 0.90 |
| FEV1/FVC | 0.009 | 0.91 | 0.10 | 0.24 |
| PaO2, mm Hg | 0.27 | 0.002 | - | |
| PaCO2, mm Hg | −0.26 | 0.002 | - | |
| SaO2 | 0.25 | 0.004 | ||
| BODE index | −0.07 | 0.48 | - | |
| 6-min. walking distance | 0.24 | 0.009 | - | |
| IL-6, pg/ml | −0.27 | 0.005 | −0.11 | 0.18 |
| IL-8, pg/ml | −0.02 | 0.84 | −0.21 | 0.012 |
| IL-1β, pg/ml | −0.07 | 0.56 | −0.13 | 0.22 |
| TGFβ, pg/ml | 0.023 | 0.84 | −0.14 | 0.11 |
| TNFα, pg/ml | 0.005 | 0.96 | −0.03 | 0.67 |
| MCP-1, pg/ml | −0.12 | 0.21 | 0.12 | 0.14 |
FEV1: forced expiratory volume in 1 second; FVC, forced vital capacity; PaO2, arterial oxygen partial pressure; PaCO2, arterial carbon dioxide partial pressure; SaO2, oxygen saturation of arterial blood; BODE Index: Body Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index; IL, interleukin; TGFβ, transforming growth factor beta; TNFα, tumor necrosis factor alpha; MCP-1, monocyte chemotactic protein-1