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. Author manuscript; available in PMC: 2016 May 9.
Published in final edited form as: Nat Med. 2005 Nov 27;11(12):1339–1345. doi: 10.1038/nm1336

Figure 4.

Figure 4

TAAs induce a TSP-1–dependent microvascular degeneration and inhibit of angiogenesis in tissue explants. (a) Representative retinal explants from newborn pigs treated with 14E-AA in the presence or absence of TSP-1– (TSP-1Ab) and CD36-specific (CD36Ab) antibodies. Scale bar, 250 μm. Values in histogram are mean ± s.e.m. of four to five explants per treatment group. **P < 0.01. (b) Representative microvascular sprouting from Matrigel-embedded aortic rings from wild-type, Tsp1−/− and CD36−/− mice exposed to 14E-AA (left panels). Scale bar, 1 mm. CD36 expression in microvascular sprouts (right colored panels); representative of two experiments. Scale bar, 100 μm. Values in histograms are mean ± s.e.m. of 19–20 explants per group. ***P < 0.01 compared with control (Ctl) and other values.