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Synthesis of Triazole-Linked Activity-Based Probes
(A) Comparison of a native diUb isopeptide linkage and the protease-resistant diUb triazole linkage.
(B) Schematic representation of the key CuAAC reaction to generate non-hydrolyzable diUb activity-based probes 3.
(C) Schematic representation of the key CuAAC reaction to generate non-hydrolyzable diUb activity reporter substrates 6.
