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The 80s loop of the C. albicans FKBP12 apo structures binds in the same pocket as the transition state mimic FK506. On the left are overlays of the three C. albicans apo FKBP12 structures with the 80s loop “substrate” included. On the right is the structure of C. albicans FKBP12-FK506. The 80s loops from the apo structures are inserted in the same way and in the same pocket as the transition state mimic FK506 (right).
