FIGURE 2.

Expression of macrophage ABCA3 and ABCB1 is induced by exposure to miltefosine. ABCA3 (A) and ABCB1 (B) gene expression was evaluated in macrophages from CL patients (n = 19) infected in vitro with L. V. panamensis (L.p) for 24 h and treated with 16 μm miltefosine dissolved in DMSO (MLF) for subsequent 24 h or left untreated. Expression of ABCA3 was also measured in uninfected THP-1 cells exposed to increasing concentrations of MLF dissolved in PBS (C). Statistical differences were determined by one-way analysis of variance followed by Tukey's multiple comparisons test. Mean values are shown. NIL, untreated control.