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. 2016 Mar 3;291(18):9733–9747. doi: 10.1074/jbc.M115.687806

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© 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — NFκB library screening in response to DETA-NO preconditioning and proposed molecular mechanism. A, heat map of NFκB library screening by real time PCR array in response to DETA-NO preconditioning (PC) at 0 and 24 h of recovery (RC). B, quantitative data to confirm up-regulated genes (mRNA level) screened from NFκB library array after preconditioning hCSCs with DETA-NO. C, representative images of Western blot showing the NO-induced expression of HO-1, COX2, MCL-1, and BCL-2 as well as phosphorylation of ERK and AKT in hCSCs expressing scrambled, STAT3, or NFκB-p65 shRNA. D, quantitative data for Western blots shown in C. E, ROS measurement. F, descriptive diagram of proposed molecular mechanism for DETA-NO-induced hCSC survival. Values are means ± S.D. Error bars represent S.D. ** or ##, p < 0.01 versus the indicated control (Ctrl); *** or ###, p < 0.001 versus the indicated control. t, total.