Figure 1.
Analysis of nanoporosity in homogenous collagen gels with densities of 2, 5, and 8 mg/mL. (A) HV-OCT images showing the distribution of GNRs, DS-OCT images showing the corresponding GNR translational diffusion rates (DT), and corresponding SEM images revealing a decrease in ECM nanoporosity with increasing collagen density. (B) Log-linear plot of probability distributions of pore areas at each collagen concentration, with lines representing a smoothed average of each. (C) Pore-area centroid values, calculated from probability distributions, decrease with increasing collagen density. Error bars represent the probability-weighted standard deviation of the pore areas measured (p < 0.01 for all comparisons).