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. 2016 Apr 26;110(8):1744–1752. doi: 10.1016/j.bpj.2016.03.027

Figure 1.

Figure 1

Structure and sequence of MCoTI-II. (A) Native structure solved by solution NMR (PDB: 1IB9) (5). Three disulfide bonds are labeled based on their Cys numbering. (B) MCoTI-II without disulfide bonds formed. Shown is just one of the denatured peptide structures after 0.05 μs of heating at 400 K. Colors as in (A). (C) Sequence of the cyclic peptide MCoTI-II with native cysteine matches labeled above, and intercysteine loops labeled below. Loop 1 contains the binding site for trypsin. To see this figure in color, go online.