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. 2016 Apr 29;6:25032. doi: 10.1038/srep25032

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(A) mRNA expression of MMP13, IL-6 and IL-8 in the chondrocytes after miR-127-5p inhibitor treatment. B. Protein abundance of OPN in the chondrocytes after pcDNA-OPN transfection. (C,D) Proliferation of chondrocytes after pcDNA-OPN transfection by MTT assay (C) and BrdU incorporation assays (D). (E,F) Proliferation of chondrocytes after indicted treatments by MTT assay (E) and BrdU incorporation assays (F). (G,H) Proliferation of chondrocytes after indicted treatments by MTT assay (G) and BrdU incorporation assays (H). (I) The activation of PI3K-Akt pathway by immunoblotting analysis. Data are representative of three independent experiments with 4–6 repeats in each time. OPN: osteopontin; PI3K: phosphatidylinositide 3-kinases; Mi-C: miR-127-5p mimics control; I-C: miR-127-5p inhibitor control.