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. 2016 Apr 14;15(4):761–773. doi: 10.1016/j.celrep.2016.03.069

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Kinetics of Remyelination in the Aging Corpus Callosum

(A) The number of TdTom+ cells in NL tissue is greater in older mice (combining data from 6-month-old and 13-month-old) (p = 0.031 and one-way ANOVA) and at 10 dpl (p = 0.002).

(B) The number of GFP+ cells decreases with age (p < 0.001 at 5 dpl and 10 dpl, p = 0.01 at 21 dpl, and one-way ANOVA).

(C) The number of TdTom+, Ki67+ cells decreases with age in NL corpus callosum (p = 0.002 and one-way ANOVA) and at 5 dpl (p = 0.004).

(D) The number of GFP+/Ki67+ cells decreases with age in the NL corpus callosum (p = 0.001 and one-way ANOVA) and at all times postlesion (5 dpl, p < 0.001; 10 dpl, p = 0.002; and 21 dpl, p < 0.001).

(E) The proportion of proliferating GFP+ cells at 5dpl is significantly fewer in 2-month-old animals compared to 12-month-old animals, but remains the same for TdTom+ cells.

(F) The number of TdTom+/CC1+ dOLs is decreased in older mice at 21 dpl (p = 0.001 and one-way ANOVA).

(G) The number of GFP+/CC1+ cells decreases with age (NL, p = 0.015; 10 dpl, p = 0.001; 21 dpl, p = 0.034; and one-way ANOVA).

(H and I) The proportion of TdTom+ dOL lineage cells that is CC1+ at 21 dpl is less in old (13-month-old) than in young (2-month-old) mice (p < 0.001 and Student’s t test), whereas (I) the proportion of vOL lineage cells that is CC1+ at 21 dpl is the same for old and young mice. The data are presented as mean ± SEM (n = 3).