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. 2016 Apr 29;6:25176. doi: 10.1038/srep25176

Figure 2. Effect of stroke on infarct volume and neurological deficit score (NDS) in socially isolated (ST- ISO) and pair-housed (ST-PH) mice.

Figure 2

(A) A significant difference (p < 0.05) was found in total hemispheric infarct between ST-ISO and ST-PH mice (37.7 ± 4.73 vs 20.0 ± 6.4) in mice sacrificed 72 hours after reperfusion. (B) Effect of housing condition on brain tissue atrophy. No changes in % tissue atrophy were observed between ST-ISO and ST-PH group after 4 weeks. (C) Congruent to infarct volume changes, ST-PH group had a significant improvement in behavioral recovery compared to ST-ISO mice 72 hours after stroke. (D) However, unlike tissue atrophy, deficits in the NDS were significantly different (p < 0.05) between ST-ISO and ST-PH group at day 28. The ST-PH mice showed progressive recovery while ST ISO mice did not recover further after the initial acute recovery during week 1.