Table 3.
Risk Stratification Models. Each risk factor was listed as odds ratios for interpretation. See the appendix for instructions on use. Each of the conditions with values for Yes and Unknown were in reference to a normal result.
| Effect | AKI Risk (OR [95% CI]) | AKI Injury (OR [95% CI]) |
|---|---|---|
| Demographics | ||
| Female | 1.22 [1.07 – 1.4] | 1.22 [1.02 – 1.47] |
| Age | ||
| 18 to 35 | 1.00 | 1.00 |
| 36 to 45 | 1.01 [0.81 – 1.25] | 1.12 [0.85 – 1.48] |
| 46 to 55 | 1.15 [0.94 – 1.41] | 1.17 [0.90 – 1.53] |
| 56 to 65 | 1.28 [1.04 – 1.57] | 1.13 [0.85 – 1.49] |
| >= 66 | 1.42 [1.17 – 1.73] | 1.35 [1.04 – 1.75] |
| Race | ||
| White | 1.00 | 1.00 |
| African American | 0.97 [0.81 – 1.17] | 1.07 [0.84 – 1.37] |
| Other | 0.96 [0.61 – 1.49] | 1.44 [0.88 – 2.34] |
| Unknown | 1.26 [1.04 – 1.52] | 1.33 [1.04 – 1.69] |
| Medication Class | ||
| Amphotericin B | 8.04 [6.19 – 10.46] | 8.39 [6.16 – 11.42] |
| Cyclosporine | 2.99 [2.33 – 3.84] | 2.10 [1.51 – 2.92] |
| Loop Diuretics | 2.08 [1.82 – 2.38] | 2.24 [1.87 – 2.69] |
| Thiazide Diuretics | 1.51 [1.23 – 1.85] | 1.89 [1.48 – 2.42] |
| Aminoglycosides | 1.53 [1.27 – 1.85] | 1.49 [1.18 – 1.89] |
| NSAID | 1.12 [0.99 – 1.28] | 1.24 [1.05 – 1.47] |
| K-Sparing Diuretics | 1.21 [0.97 – 1.51] | 1.19 [0.90 – 1.57] |
| Acyclovir | 0.98 [0.77 – 1.25] | 0.66 [0.48 – 0.91] |
| Cisplatin | 0.62 [0.33 – 1.15] | 0.37 [0.13 – 1.05] |
| CT Scan w/ Contrast | 0.92 [0.79 – 1.08] | 0.85 [0.69 – 1.04] |
| ARB | 0.96 [0.70 – 1.33] | 0.78 [0.49 – 1.25] |
| ACEI | 0.80 [0.69 – 0.94] | 0.70 [0.56 – 0.88] |
| Clinical Condition Associations (Lab) | ||
| Mean Admission Creatinine | 0.72 [0.51 – 1.03] | 0.54 [0.33 – 0.87] |
| Bacterial Infection (Any Antibiotic Use) | 1.74 [1.45 – 2.10] | 2.84 [2.09 – 3.84] |
| Myocardial Infarction | ||
| Yes | 1.11 [0.85 – 1.44] | 1.45 [1.05 – 1.99] |
| Unknown | 0.89 [0.62 – 1.29] | 1.10 [0.71 – 1.71] |
| Rhabdomyolysis | ||
| Yes | 0.98 [0.65 – 1.50] | 0.93 [0.54 – 1.62] |
| Unknown | 1.00 [0.70 – 1.45] | 0.75 [0.49 – 1.16] |
| Acute Hepatitis | ||
| Yes | 1.65 [1.28 – 2.12] | 1.86 [1.38 – 2.52] |
| Unknown | 1.03 [0.78 – 1.36] | 0.89 [0.60 – 1.31] |
| Acute Pancreatitis | ||
| Yes | 0.84 [0.64 – 1.11] | 0.82 [0.59 – 1.15] |
| Unknown | 0.90 [0.73 – 1.10] | 0.86 [0.67 – 1.12] |
| Hyperammonemia | ||
| Yes | 1.38 [0.85 – 2.23] | 1.86 [1.02 – 3.40] |
| Unknown | 0.85 [0.60 – 1.19] | 1.06 [0.68 – 1.66] |
| AST/ALT Ratio > 1.5 | ||
| Yes | 1.86 [1.58 – 2.18] | 1.73 [1.40 – 2.13] |
| Unknown | 1.01 [0.82 – 1.26] | 0.88 [0.66 – 1.18] |
| Thrombocytopenia | ||
| Yes | 1.76 [1.53 – 2.03] | 2.11 [1.75 – 2.54] |
| Unknown | 0.84 [0.60 – 1.17] | 1.00 [0.62 – 1.61] |
| Leukocytosis | ||
| Yes | 1.00 [0.88 – 1.14] | 1.09 [0.92 – 1.3] |
| Unknown | 0.97 [0.62 – 1.51] | 1.25 [0.68 – 2.3] |
| Hypercalcemia (Corrected) | ||
| Yes | 1.52 [1.06 – 2.18] | 1.05 [0.62 – 1.79] |
| Unknown | 1.03 [0.84 – 1.26] | 1.09 [0.83 – 1.42] |
| Mean Glucose | ||
| >250 | 2.68 [2.06 – 3.5] | 2.57 [1.76 – 3.75] |
| 200 – 250 | 1.6 [0.82 – 3.12] | 1.87 [1.37 – 2.57] |
| 150 – 199 | 1.00 [0.88 – 1.14] | 1.39 [1.13 – 1.72] |
| Unknown | 0.97 [0.62 – 1.51] | 0.85 [0.24 – 3.00] |