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. 2016 Apr 29;17:313. doi: 10.1186/s12864-016-2634-1

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© Donaldson et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Opioid-induced changes in nociceptive thresholds for 23 strains of mice. These data were reproduced from our earlier report [18]. In panel (a) the reduction in mechanical nociceptive thresholds are displayed as a fraction of the baseline thresholds. The strains are displayed from the most to least robustly changed. In panel (b) thermal withdrawal thresholds measured using a Hargreaves’ apparatus are displayed as a fraction of baseline threshold. In panel (c) changes in thermal withdrawal threshold of the tail (tail flick) response are provided. For each trait the mean value is displayed +/− S.E.M., n = 8 mice per strain