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. 2016 Apr 29;17:313. doi: 10.1186/s12864-016-2634-1

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© Donaldson et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Morphine tolerance, dependence and weight change for 23 strains of mice. Some data were reproduced from our earlier report [18]. In panel (a) the fold change in the ED₅₀ values for morphine dose–response curves are provided. In panel (b) the number of jumps exhibited by the mice in the 15 min period following the administration of naloxone are displayed. In panel (c) the change in weight as a fraction of baseline for each of the 23 strains used in these experiments are provided. For each trait the mean value is displayed +/− S.E.M., n = 8 mice per strain