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. 2016 Apr 29;17:313. doi: 10.1186/s12864-016-2634-1

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© Donaldson et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Opioid adaptations in C57BL/6 wild-type and Mpdz ^+/− mice. In panel (a) the results of experiments measuring opioid-induced hyperalgesia using changes in mechanical withdrawal thresholds are displayed. In panel (b) the anangesic effect of cumulitive doses of morphine are shown for wild-type and Mpdz ^+/− mice both before and after 4 days of escalating dose morphine treatment. In panel (c) naloxone-induced jumping behavior for wild-type and Mpdz ^+/− mice is displayed. Finally, in panel (d) data for morphine-induced weight loss are provided. For each trait the mean value is displayed +/− S.E.M., n = 8 mice per strain. ##, **p < 0.01, ###, ****p < 0.001