Table 3.

SuperPaths overrepresented among genes downregulated in the inner cell mass by CSF2

ERK signaling (score = 22.99)—51 genes

ACTA2, ACTG2, ADCY8, ALK, ARHGDIB, ARHGEF6, CACNB3, CACNA1G, CCL5, CDH2, CDH9, COL1A1, DES, EFEMP1, EPHA3, ESR2, FGF16, FOSB, FOSL1, GNA11, GNA12, GNAT2, IL11RA, IL12RB2, IL15RA, IL20, IL4, IL7, IRAK1, LEF1, MAPK12, MYH1, MYLPF, MYO18B, MYO7A, MUC1, MYC, NCAN, PAK3, PPP1R3C, SEMA4G, SMAD9, SOX11, SOX30, STAT6, TGFBR3, TIMP2, TNFAIP6, TNFSF9, TNFSF11, VIM

Integrin pathway (score = 16.42)—28 genes

ACTA2, ACTG2, ADCY8, ARHGEF6, CACNA1G, CACNB3, CAV1, CCL5, CLDN1, COL1A1, EFEMP1, GNA11, GNA12, GNAT2, MAPK13, MMP9, MYC, MYH1, MYLPF, MYO18B, MYO7A, NCAN, NOX1, PAK3, STAT6, TGFBR3, THBS1, VAV3

Visual cycle (score = 14.74)—10 genes

GNA11, GNA12, GNAT2, GUCA1A, GUCY2C, LRAT, PDE6A, RDH10, RDH12, SLC24A1

Akt signaling (score = 14.45)—30 genes

ACTA2, ACTG2, AKR1B1, ALK, ATXN7, CCL5, EPHA3, FGF16, FOSL1, GABRG1, GNA11, GNA12, GNAT2, IL11RA, IL12RB2, IL15RA, IL20, IL4, IL7, IRAK1, MAPK13, PAK3, SEMA4G, STAT6, TIMP2, TLR7, TNFAIP6, TNFSF11, TNFSF9, VAV3

Shown are those SuperPaths that were highly significant (P < 0.001). Note that there were no SuperPaths identified in the list of genes upregulated in the ICM by CSF2