Table 4.

SuperPaths overrepresented among genes upregulated in the trophectoderm by CSF2

Inhibitory actions of lipoxins on superoxide production in neutrophils (score = 25.39)—9 genes

FOS, GNG12, GNG2, GNGT2, JUN, PLD1, NFKBIA, PIK3CG, PREX1

Translation regulation by alpha-1 adrenergic receptors (score = 19.66)—8 genes

ADRA1A, FOS, GNG12, GNG2, GNGT2, JUN, PLD1, PRKCE

Hypertrophy model (score = 18.66)—5 genes

ANKRD1, ATF3, CYR61, HBEGF, IFNG

Apoptotic pathways in synovial fibroblasts (score = 16.29)—22 genes

ANK1, ARHGDIB, CACNA2D1, CTGF, FOS, GNG12, GNG2, GNGT2, HBEGF, ITGB3, JUN, KITLG, KLF10, MAP3K8, NFKBIA, NRP1, PLD1, PPARA, PPP1R14A, PRKCE, RHOB, ZAP70

G-protein signaling ras family gtpases in kinase cascades (score = 15.90) 8 genes

CYR61, FOS, FOSB, JUN, LDLR, NFKBIA, PRKCE, SIPA1

Toll comparative pathway (score = 15.54) 8 genes

ATF3, FOS, FOSB, GNG2, IFNG, IL1RAP, JUN, NFKBIA

ERK signaling (score = 15.12) 29 genes

ARHGDIB, ATF3, CACNA2D1, CAPN11, CTGF, DUSP1, FOS, FOSB, GNG12, GNG2, GNGT2, HBEGF, IL17A, ITGB3, JUN, KITLG, KLF10, MAP3K8, NFKBIA, NRP1, PIK3CG, PLD1, PPP1R14A, PRKCE, RHOB, SMAD9, SPP1, TNFRSF8, ZAP70

Osteopontin-mediated events (score = 15.0)—5 genes

FOS, ITGB3, JUN, NFKBIA, SPP1

ATF-2 transcription factor network (score = 14.65)—6 genes

ATF3, DUSP1, DUSP5, FOS, IFNG, JUN

Angiotensin activation of ERK (score = 14.51)—11 genes

FOS, GNG12, GNG2, GNGT2, HBEGF, KITLG, ITGB3, JUN, PIK3CG, PRKCE, ZAP70

LPA receptor mediated events (score = 13.79)—6 genes

FOS, GNG2, HBEGF, JUN, NFKBIA, PRKCE

Shown are those SuperPaths that were highly significant (P < 0.001)