Table 1.
Brain tissue information for ASD patients and controls
| Pair no. | Case no.a | BA | Diagnosis | Age (years)b | Sex | PMI (h)c | Cause of death | Intellectual disability | Epilepsy | Other features | Drug therapies at time of deathd |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | AN11989 (B6677) | 41/42 | Autism | 20 | M | 16 | Cardiac arrest | Yes | Yes | – | Heart medication, Zoloft, clomipramine |
| 2 | AN08792 (B5173) | 41/42 | Autism | 30 | M | 20 | Gastrointestinal hemorrhage | Yes | Yes | Large ear lobes | Dilantin, Depakote, Tranxene bid, cisapride, clorazepate, folic acid, oxcarbazepine |
| 3 | AN00764 (B5144) | 22 | Autism | 20 | M | 23.7 | Trauma | Yes | No | – | None |
| 4 | AN17138 (B6294) | 41/42 | Autism | 16 | M | Unknown | Seizure | Unknown | Yes | Inherited 15q duplication | Topamax, Depakote, Allegra, Claritin, NuThera multivitamin |
| 5 | AN09730 (B6337) | 22 | Autism | 22 | M | 25 | Seizure | Yes | Yes | Intestinal lymphadenopathy, hypertrophic spleen, recurrent otitis | Lamictal, Zonegran, Neurontin, Abilify, flax seed oil, omega-3, multivitamin |
| 6 | AN01570 (B6184) | 41/42 | Autism | 18 | F | 6.75 | Seizure | Unknown | Yes | Focal slowing in the left parieto-occipital area | None |
| 1 | AN10833 (B5718) | 41/42 | Control | 22 | M | 21.5 | Unknown | No | No | – | None |
| 2 | B4211 | 41/42 | Control | 30 | M | 23 | Cardiac arrhythmia | No | No | – | None |
| 3 | AN04432 (B3829) | 22 | Control | 22 | M | 12 | Central hepatic laceration | No | No | – | None |
| 4 | AN17425 (B6207) | 22 | Control | 16 | M | 26 | Ischemic heart attack | No | No | – | None |
| 5 | AN14368 (B6221) | 41/42 | Control | 22 | M | 24 | Unknown | No | No | – | None |
| 6 | UMB1541 | 22 | Control | 20 | F | 19 | Head injuries | No | No | – | None |
BA Brodmann area, PMI post-mortem interval
aAutism Tissue Program identifier
bMean age (±SD) for the autism group = 21.0±2.9, for controls = 22.0±1.8; t = −0.368, df = 10, p = 0.721
cMean PMI (±SD) for the autism group = 18.2+3.2, for controls = 20.9±2.0, t = −0.707, df = 9, p = 0.497
dPharmacological therapy from the last available report, dating back to less than a year prior to death