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. Author manuscript; available in PMC: 2016 Oct 8.
Published in final edited form as: Science. 2016 Apr 7;352(6282):231–235. doi: 10.1126/science.aad4017

Figure 4. NAD+ recycling rescues proliferation in cells with impaired ETC.

Figure 4

(A) Effect of pyruvate, oxaloacetate, lactate and malate addition on proliferation of HeLa Tet3G Luciferase cells in the presence of 200 µM uridine and in the presence or absence of 1 µM piericidin. Mean ± S.E., n=5 independent experiments. (B) Effect of LbNOX and mitoLbNOX expression in HeLa cells on inhibition of cell proliferation by 1 µM piericidin, 1 µM antimycin, 10 µg/ml chloramphenicol and 30 ng/ml ethidium bromide in the presence of 200 µM uridine. Mean ± S.E., n=3 independent experiments.