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. 2016 Apr 29;10:36. doi: 10.3389/fnsys.2016.00036

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Copyright © 2016 Dash, Hergenroeder, Jeter, Choi, Kobori and Moore.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary illustration of methionine metabolic pathways. Metabolites of the transmethylation pathway are indicated in red, the transsulfuration pathway is indicated in blue, and the gamma-glutamyl cycle is shown in green. Black arrowhead (▴) indicates changes in metabolite levels in the plasma of sTBI patients. Open arrows (▵) indicate significant changes measured in the mTBI patients as compared to HV. Up arrowheads indicate increased levels, whereas down arrowheads indicate decreased levels.