Table 3.

Average number of variants by model before and after filtering

Model	Filtered calls	CADD >20	1000 Genomes MAF <0.05	Databases
De novo	110,794	46	33	2
X-linked	327,170	1017	153	0
Autosomal recessive	143,578	466	14	0
Compound heterozygous	1380	NA	0	0

CADD, combined annotation-dependent depletion; MAF, multiple alignment format.