Table V. Relationship Between Potential Mediators and Improvement, Using Median Regression (Adjusted for Baseline Incontinence Frequency).

Also shown, for illustrative purposes, are the mean values, as well as the difference in the means, before and after therapy, stratified by responder/non-responder status.

			Responders n=100 ‡			Non-responders n=83 ‡
DOMAINS and variables in regression equation	Median regression coefficient adjusted	p	pre	post	post– pre	pre	post	post– pre
PROPRIOCEPTION
First sensation of filling (ml)	−0.030 ±0.040	0.45	217 ±102	212 ±95	−5 n=67	198 ±114	210 ±109	2 n=50
First desire to void (ml)	0.057 ±0.033	0.08	295 ±126	336 ±148	43	276 ±136	293 ±150	17
Strong desire to void (ml)	0.027 ±0.034	0.43	412 ±168	443 ±169	31	393 ±174	406 ±188	13
Warning,1st desire to capacity (ml)	−0.013 ±0.027	0.63	288 ±117	230 ±152	−58	273 ±165	247 ±138	−26
Warning, 1st sensation to capacity (ml)	0.016 ±0.032	0.61	392 ±137	356 ±172	−36 n=65	351 ±188	324 ±172	−27 n=50
Warning, strong desire to capacity (ml)	0.001 ±0.022	0.96	163 ±137	115 ±142	−48	159 ±145	127 ±134	−32
warning 1st desire to DO onset (ml) *	0.002 ±0.097	0.98	139 ±136	137 ±184	−2 n=19	125 ±103	158 ±131	33 n=23
DO CHARACTERISTICS
DO velocity (cm H2O/s)	5.6 ±4.9	0.26	1.64 ±1.14	2.26 ±1.77	0.62 n=20	3.15 ±2.91	2.82 ±2.81	−0.33 n=27
DO amplitude (cm H2O)	0.40 ±0.70	0.57	19.5 ±12.7	18.2 ±8.1	−1.3 n=21	29.4 ±25.1	24.4 ±12.9	−5 n=27
DO, onset volume (ml)*	−0.043 ±0.057	0.45	389 ±187	392 ±212)	3 n=21	331 ±166	402 ±203	71 n=27
URETHRAL SPHINCTER
MUCP (cm H2O)	−0.039 ±0.35	0.91	49.3 ±17.6	49.4 ±18.9	0.1	52.9 ±25.3	53.0 ±24.9	0.1
Squeeze pressure, BN (cm H2O)	0.42 ±0.29	0.15	23.3 ±16.9	24.3 ±15.2	1	29.1 ±21.0	25.6 ±18.0	−4
Squeeze pressure, striated sphincter *	0.12 ±0.26	0.63	26.7 ±17.7	24.8 ±17.2	2 n=77	28.8 ±19.7	26.3 ±16.4	−3 n=62
DETRUSOR CONTRACTILITY
PVR (ml)	−0.001 ±0.026	0.96	62 ±113	59 ±98	−3	55 ±89	62 ±109	7
DECO contraction strength coefficient *	−0.25 ±0.14	0.08	103 ±40	101 ±38	−2 n=86	102 ±42	99 ±38	−3 n=68
Peak isovolumetric pressure (cm H2O)	−0.093 ±0.59	0.87	28 ±11.9	28 ±13	0 n=36	31.2 ±12.8	33.0 ±14	2 n=22
CLINICAL DOMAINS
24-h voiding frequency	−3.63 ±1.90	0.06	8.9 ±3.0	7.4 ±1.7	−1.5	8.5 ±2.3	8.0 ±1.9	−0.5
24-h voided volume (ml) *	−0.020 ±0.009	0.02	1876 ±702	1769 ± 704	−107	1747 ±780	1677 ± 719	−70
24-h diuresis (ml/24 h)	−0.021 ±0.008	0.01	1908 ±703	1776 ± 707	−132	1803 ±779	1713 ± 716	−90

^‡Total number of responders and non-responders. Numbers of subjects (n) in individual comparisons are all at least 90% of this total except where explicitly noted. For explanation of missing values see text.

^*Variable postulated a priori to best represent each domain.