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. Author manuscript; available in PMC: 2016 Jul 14.
Published in final edited form as: Nature. 2016 Jan 14;529(7585):212–215. doi: 10.1038/nature16504

Figure 1. Taxa reduction observed in low-MAC diet is largely reversible in a single generation.

Figure 1

a, Schematic of mouse experiment. Humanized mice (n=10) were maintained on a high-MAC diet for four weeks after which half of the mice were switched to a low-MAC diet for 7 weeks. These mice were then switched back to the high-MAC diet for >4 weeks. b, Principle coordinate analysis of the UniFrac distance for 16S rRNA amplicon profiles from fecal samples collected from the diet switching mice (yellow, n=5) and control high-MAC diet mice (green, n=5). c, Distribution of OTUs fold changes for diet switching (blue, n=5) or control (red, n=5) groups comparing baseline (4 weeks post-humanization) versus week 9 (5 weeks post-low MAC diet for “diet switch” group; top panel) and baseline versus week 15 (4 weeks after return to high-MAC diet for “diet switch” group, bottom panel).