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. Author manuscript; available in PMC: 2016 Jul 14.
Published in final edited form as: Nature. 2016 Jan 14;529(7585):212–215. doi: 10.1038/nature16504

Extended Data Figure 5. Fraction of high-confidence OTUs from the Clostridiales order increases and from the Bacteroidales order decreases over multiple generations in the low-MAC consuming mice.

Extended Data Figure 5

a, Percent of high-confidence OTUs, grouped by order, detected in mice feces over four generations in the diet-switching lineage on the low-MAC diet (low) and high-MAC diet (hi) (n=5 for Gen 1; n=6 for Gen 2-4). b, Percent of high-confidence OTUs, grouped by order, detected in mice feces over four generations in the control high-MAC diet lineage at the equivalent time points to the high-MAC diet (a) and low-MAC diet (b) of the diet-switching group (n=5 for Gen 1; n=6 for Gen 2–4). c, Imputed gycloside hydrolase family members (GH) that show significant differences (at least 2-fold change and p<0.05, Bonferroni-corrected t test) between generation 4 diet-switching mice after four weeks on the high MAC diet (teal) (n=5) and the starting generation one mice (salmon) (n=10). Error bars depict s.e.m. No GH families showed significant changes in the control group.