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. Author manuscript; available in PMC: 2016 Apr 29.
Published in final edited form as: Nanotoxicology. 2011 Aug 10;6(7):724–735. doi: 10.3109/17435390.2011.606926

Figure 4.

Figure 4

Nanoparticle inhalation alters arteriolar responsiveness to sympathetic stimulation following L-NMMA and phentolamine treatment. PVNS was performed as described in the Methods. (A) Nano-TiO2 exposure did not alter responsiveness to sympathetic arteriole constriction during normal PSS superfusion (n = 23 control, 27 nano-TiO2-exposed arterioles). (B) Treatment with L-NMMA increased arteriolar constriction in control animals but not nano-TiO2-exposed animals (n = 10 control, 12 nano-TiO2-exposed arterioles). (C) Nano-TiO2 exposure increased sensitivity to α-adrenergic blockade during sympathetic arteriolar constriction (n = 10 control, 11 nano-TiO2-exposed arterioles). (D) Tetrodotoxin significantly ablated arteriolar constriction in all groups (n = four control, nine nano-TiO2-exposed arterioles). Values are means ± SE. *p < 0.05 vs. control at same stimulation frequency, †p < 0.05 vs. normal superfusate at the same frequency.