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. Author manuscript; available in PMC: 2017 Jan 22.
Published in final edited form as: Circ Res. 2015 Nov 12;118(2):203–215. doi: 10.1161/CIRCRESAHA.115.307399

Figure 6. Probing the molecular nature of the differential ionic currents.

Figure 6

A. 100 µM CdCl2 was able to block the fast component (iearly), in a reversible manner (n=3 hearts). B. Comparison of the amplitude and kinetics of iearly during CdCl2 treatment. C. Effect of 10 µM SEA0400 on epicardial APs. SEA0400 is a potent blocker of NCX and had a similar effect as Ry and Tg treatment on the AP repolarization (n=6 hearts). D. Effect of SEA0400 on the amplitude of epicardial Ca2+ transients. As expected, NCX’s block induced an increase in the Ca2+ transient amplitude (n=3 hearts). E. Effect of SEA0400 on the photolytically activated ionic currents (n=3 hearts). F. Histogram showing that SEA0400 had a selective effect on ilate indicating that in mouse epicardium, an NCX current activated by SR Ca2+ release is involved in the genesis of AP phase 2. * Populations means are significantly different at a level of 0.05 (ANOVA).