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. Author manuscript; available in PMC: 2016 Apr 29.
Published in final edited form as: Cancer Cell. 2013 Apr 15;23(4):427–428. doi: 10.1016/j.ccr.2013.04.003

Figure 1. SIRT4: The Glutamine Gatekeeper.

Figure 1.

DNA damage (1) elicits the DDR (2) that, through undefined mechanisms (indicated with a question mark), results in enhanced SIRT4 transcription (3) and higher SIRT4 activity in the mitochondria (4). In turn, SIRT4 inhibits glutamine conversion into αKG by inhibiting glutamate dehydrogenase (GDH) (5). Decreased αKG shuts down the anaplerotic replenishment of the tricarboxylic acid cycle (TCA) (6), which, through mechanisms that remain to be clarified (question mark), result in arrest and DNA repair (7).