Skip to main content
. Author manuscript; available in PMC: 2016 Apr 29.
Published in final edited form as: Nat Struct Mol Biol. 2009 Jun 21;16(7):769–776. doi: 10.1038/nsmb.1623

Figure 6.

Figure 6

Increased chromosomal translocations by AID upmutants. (a) Scheme of reciprocal translocation between c-myc and IgH locus indicating the primers used for PCR amplification (arrows) and the probes (P) used for Southern blot hybridization. (b) Chromosome 15 and 12 derived translocations (der Chr 15, der Chr 12) were amplified by PCR on three independent pools of genomic DNA from 2 × 105 cell-equivalents of AID-deficient B cells retrovirally transduced with pMx-GFP constructs directing the expression of either wild type or Mut7.3 AID.