Figure 1.

(A) A representative autoradiograph showing the total binding of [³H]AF-DX 384 to human cortex with non-specific binding shown in the boxed insert.

(B) The specific binding (mean ± SEM) of [³H]AF-DX 384 to Brodmann’s areas (BA) 24 and 46 from subjects with bipolar disorder, major depressive disorder and age and sex matched controls.

(C) A representative autoradiograph showing activated [³⁵S]GTPγS binding in the presence of oxotremorine-M with basal levels of binding shown in the boxed insert.

(D) Oxotremorine-M stimulated [³⁵S]GTPγS binding (mean ± SEM) to Brodmann’s areas (BA) 24 and 46 from subjects with bipolar disorder, major depressive disorder and age and sex matched controls.

*p < 0.05, **p < 0.01.