. 2015 Oct 16;19(4):pyv118. doi: 10.1093/ijnp/pyv118

Table 2.

A Comparison of Levels (mean ± SEM) of [³H]AF-DX 384 Binding, CHRM2 Protein, and Oxotremorine-M-Stimulated [³⁵S]GTPγS Binding in BA 24 and BA 46 from Suicide Completers and Those Who Died from Other Causes

Comparison between all cases
Assay	Region	Suicide Completion	Nonsuicide	P value
[³H]AF-DX 384 binding^a	BA 24	53.5±5.80	70.4±2.80	P<.01
[³H]AF-DX 384 binding^a	BA 46	52.5±5.50	66.3±2.30	P=.01
CHRM2 protein^b	BA 24	0.52±0.08	0.83±0.09	P=.02
CHRM2 protein^b	BA 46	0.51±0.08	0.45±0.04	P=.49
[³⁵S]GTPγS binding^a	BA 24	18.5±4.60	29.3±4.00	P=.10
[³⁵S]GTPγS binding^a	BA 46	19.8±4.80	24.8±4.20	P=.46
Comparison between mood disorder cases
[³H]AF-DX 384 binding^a	BA 24	53.5±5.80	57.4±4.00	P=.61
[³H]AF-DX 384 binding^a	BA 46	52.5±5.50	61.1±4.70	P=.27
CHRM2 protein^b	BA 24	0.52±0.08	0.67±0.13	P=.31
CHRM2 protein^b	BA 46	0.51±0.08	0.50±0.06	P=.91
[³⁵S]GTPγS binding^a	BA 24	18.5±4.60	19.3±5.10	P=.91
[³⁵S]GTPγS binding^a	BA 46	19.8±4.80	23.3±5.90	P=.64

Abbreviations: BA, Brodmann’s area; CHRM2, muscarinic M2 receptor.

^afmol / mg estimated tissue equivalents.

^bratio of internal control.