Table 1.

Efficacy of MAP4343 vs Fluoxetine to Prevent Changes Induced by Psychosocial Stress in Tree Shrews

	MAP4343-Treated Group	Fluoxetine-Treated Group
Body weight loss	-	-
LMA reduction	+	n.d.
Cortisol increase	+/-	-
Noradrenaline increase	+	+
CBT elevation	+	+
Sleep disturbances	+	+/-

Abbreviations: CBT, core body temperature; LMA, locomotor activity; n.d., not determined (accidental troubles in the animal room have precluded obtaining of quantitative results); + refers to significant efficacy preventing physiological changes; +/- refers to variable efficacy preventing physiological changes; - refers to an absence of efficacy preventing physiological changes;