Table 1. Changes in IFN-γ ELISPOT T cell responses specific for T. cruzi antigens in long-term follow-up of chronic Chagas disease patients treated with benznidazole.
Patient group | N | Clinical stage | IFN-γ-ELISPOT responses | IFN-γ-ELISPOT responses | |
---|---|---|---|---|---|
at 36 months post-treatment | 48–72 months post treatment | ||||
G0 | G1 | relative to pretreatment A [30] | |||
1 | 12 | 9 | 3 | Became undetectable | Rebound |
2 | 6 | 5 | 1 | Decreased | Unchanged |
3 | 5 | 4 | 1 | Became detectable B | Unchanged |
4 | 8 | 7 | 1 | Unchanged | Unchanged |
Note. A Ages are not significant different among groups.
B IFN-γ-producing T cells are undetectable prior to treatment and became detectable following treatment.