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. 2016 Apr 29;10(4):e0004657. doi: 10.1371/journal.pntd.0004657

Table 1. Changes in IFN-γ ELISPOT T cell responses specific for T. cruzi antigens in long-term follow-up of chronic Chagas disease patients treated with benznidazole.

Patient group N Clinical stage IFN-γ-ELISPOT responses IFN-γ-ELISPOT responses
at 36 months post-treatment 48–72 months post treatment
G0 G1 relative to pretreatment A [30]
1 12 9 3 Became undetectable Rebound
2 6 5 1 Decreased Unchanged
3 5 4 1 Became detectable B Unchanged
4 8 7 1 Unchanged Unchanged

Note. A Ages are not significant different among groups.

B IFN-γ-producing T cells are undetectable prior to treatment and became detectable following treatment.