Skip to main content
. 2016 May;89(5):521–540. doi: 10.1124/mol.115.103044

Fig. 6.

Fig. 6.

NDRG1 expression inhibits HT29 and DU145 tumor cell migration (A and B) and cell-collagen I adhesion (C and D) via inhibition of FAK/paxillin signaling. (A and B) The HT29 and DU145 cells (i.e., sh-Control and sh-NDRG1 clones) were incubated with either the FAK inhibitor PF-562271 (10 µM) (A) or si-FAK (B) and displayed markedly inhibited migratory ability, relative to untreated or si-Con groups. (C and D) The inhibitory effect of the FAK phosphorylation inhibitor PF-562271 (C) or si-FAK (D) on cell-collagen I adhesion in both HT29 and DU145 cell-types (sh-Control and sh-NDRG1). All data are shown as mean ± S.D. (n = 3). Scale bars: 200 μm. **P < 0.01; ***P < 0.001.