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. 2016 May;44(5):720–731. doi: 10.1124/dmd.116.069419

Fig. 4.

Fig. 4.

Intraperitoneal injection of GL decreases serum ALT and AST level at the early stage after APAP challenge. (A) Mouse experiment procedure scheme. (B, C) Time course of serum ALT and AST levels after APAP challenge. (D, E) Pharmacokinetic distribution of GL and GA in serum (D) and liver (E) in GL100 (ip)/APAP-treated mice. Data are expressed as mean ± S.E.M., n = 3 in each group for control mice and n = 6 for other groups. #P < 0.05 and ##P < 0.01 versus control mice. *P < 0.05, **P < 0.01, and ***P < 0.001 versus APAP-overdosed mice.