TABLE 1.
Spectroscopic binding constants and nature of difference binding spectrum induced by ligand binding to CYP2W1
| Compounds | Binding Constant (Ks) | Binding Mode |
|---|---|---|
| All-trans retinol | 40.3 ± 7.0 nM | Type 1 |
| All-trans retinal | 55.2 ± 14.0 nM | Type 1 |
| All-trans retinoic acid (atRA) | 63.7 ± 5.9 nM | Type 1 |
| Lanosterol | nd | nd |
| Cholesterol | nd | nd |
| Progesterone | nd | nd |
| Cortisone | nd | nd |
| Hydrocortisone (cortisol) | nd | nd |
| 17β-Estradiol | 30.1 ± 11.2 μM | Reverse type 1 |
| Testosterone | nd | nd |
| Ergocalciferol (vitamin D2) | nd | nd |
| Cholecalciferol (vitamin D3) | nd | nd |
| Farnesol | 23.8 ± 9.0 μM | Reverse type 1 |
| Geraniol | nd | nd |
| Geranylgeraniol | 25.0 ± 0.3 μM | Type 1 |
| Arachidonic acid | 64.5 ± 39.1 μM | Type 1 |
| Lauric acid | nd | nd |
nd, not detectable.