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CYP26A1 and CYP26B1 homology models with tazarotenic acid docked in the active site. Docking of tazarotenic acid in the active sites of CYP26A1 (A) and CYP26B1 (C) suggested metabolism at or near the sulfur atom of the benzothiopyranyl ring system was the preferred site of metabolism. Similar binding orientations were observed for tazarotenic acid sulfoxide in the active sites of CYP26A1 (B) or CYP26B1 (D).
