Fig. 2.

Effect of single pretreatment of l-THP and LDN on cocaine reinstatement. In the experimental session following extinction, animals were administered intraperitoneal injections of l-THP and LDN 30 minutes prior to a priming dose of 10 mg/kg cocaine. Two-way ANOVA showed that 3 mg/kg l-THP and 0.1 mg/kg LDN (n = 5) and 5 mg/kg l-THP and 0.1 mg/kg LDN (n = 9) dose-dependently and significantly inhibited reinstatement of cocaine-seeking behavior assessed by active lever presses. *P < 0.5, **P < 0.01 respectively, compared with vehicle group (n = 7). Values expressed as mean ± S.E.M.