Fig. 3.

Effect of 10 days administration of l-THP and LDN on cocaine reinstatement. Animals received intraperitoneal injections for 10 days until extinction was reached. In the experimental session following, animals were primed with 10 mg/kg cocaine and placed back into operant chambers. (A and B) Extinction timeline, arrows representing administration of l-THP (3 mg/kg, n = 9 and 5 mg/kg, n = 10), LDN (0.1 mg/kg, n = 6), or l-THP and LDN combinations (3 mg/kg and 0.1 mg/kg, n = 10, and 5 mg/kg and 0.1 mg/kg, n = 11). (C) Significantly inhibited reinstatement of drug-seeking behavior assessed by active lever responses, expressed as mean ± S.E.M. Bonferroni post-hoc analysis determined that both the combinations of 3 mg/kg l-THP and 0.1 mg/kg LDN and 5 mg/kg l-THP and 0.1 mg/kg LDN were more efficacious than any of the single doses. *P < 0.5, **P < 0.1, ***P < 0.001, ****P < 0.0001 compared with vehicle group (n = 7).