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. 2016 May;357(2):248–257. doi: 10.1124/jpet.115.229542

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Fig. 4. — Effect of l-THP and LDN on spontaneous locomotion. Animals established a baseline over 3 consecutive days; following that they were given intraperitoneal injections of the assigned treatments for 10 days. Values are expressed as mean of the locomotor score ± S.E.M., n = 6 for all groups. Two-way ANOVA determined treatment had a significant effect on spontaneous locomotion. ****P < 0.0001. (A) l-THP (3 mg/kg and 5 mg/kg) produced a dose-dependent reduction on locomotion, and LDN (0.1 mg/kg) had no effect on locomotion. (B) Effect of coadministration of l-THP and LDN.