TABLE III.
SNP Associations With Suicidal Behavior and MDD in Live and Postmortem Subjects (Uncorrected P-Values)
Y = attempted suicide/suicide death |
Y = MDD |
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---|---|---|---|---|---|---|---|---|---|---|
Postmortem |
Live |
Live MDD |
Live |
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Suicide death (n = 121) versus sudden death (n = 88) |
Suicide attempters (n = 86) versus non-attempters (n = 190) |
Attempters with MDD (n = 86) versus Attempters without MDD (n = 132) |
MDD (n = 218) versus no diagnosis (n = 56) |
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Gene | SNP | Alleles | P-value | Risk genotype | P-value | Risk genotype | P-value | Risk genotype | P-value | Risk genotype |
GABBR2 | rs10739615 | A:G | 0.49 | 0.52 | 0.93 | 0.04 | GG | |||
rs2808536 | C:A | 0.02 | CC | 0.28 | 0.22 | 0.41 | ||||
GABRA4 | rs12506608 | A:G | 0.02 | AG | 0.51 | 0.61 | 0.75 | |||
rs6447520 | G:A | 0.13 | 0.01 | AA | 0.01 | AA | 0.44 | |||
GABRA5 | rs140685 | A:G | 0.04 | AG | 0.64 | 0.67 | 0.75 | |||
GABRB3 | rs8041610 | A:C | 0.01 | AC | 0.47 | 0.79 | 0.51 | |||
GABRD | rs13303016 | A:G | 0.87 | 0.30 | 0.57 | 0.04 | AA | |||
GABRG1 | rs976156 | G:A | 0.02 | GG | 0.81 | 0.73 | 0.76 | |||
GABRG2 | rs424740 | T:A | 0.03 | AA | 0.55 | 0.51 | 0.64 | |||
GLS | rs13035504 | G:C | 0.98 | 0.03 | GG | 0.02 | GG | 0.81 | ||
GRIA2 | rs6849345 | A:G | 0.04 | AA | 0.52 | 0.34 | 0.04 | AG | ||
GRIK1 | rs363527 | G:A | 0.10 | 0.73 | 0.99 | 0.03 | AA | |||
GRIN2A | rs1420040 | A:G | 0.43 | 0.79 | 0.64 | 0.02 | AG | |||
rs3785185 | G:A | 0.79 | 0.06 | 0.08 | 0.01 | AA | ||||
rs4780886 | G:A | 0.02 | AA | 0.51 | 0.61 | 0.64 | ||||
SLC1A2 | rs10836356 | G:A | 0.53 | 0.03 | AA | 0.09 | 0.11 | |||
SLC1A3 | rs1529461 | G:A | 0.72 | 0.35 | 0.04 | AA | 0.44 | |||
SLC6A1 | rs1062246 | A:G | 0.01 | AA | 0.49 | 0.36 | 0.02 | GG | ||
GAD2 | rs2236418 | A:G | 0.73 | 0.03 | GG | 0.04 | GG | 0.66 |
Gene associations with suicidal behavior and depression were all adjusted by age and sex.