Table 1. Clinical characteristics of the 37 patients with brain metastasis from thyroid cancer.
| Characteristics | No. of patients (%) |
|---|---|
| Age at diagnosis of brain metastasis (years) | |
| Median (range) | 63 (39–78) |
| Time from diagnosis of thyroid cancer to BM (years) | |
| Median (range) | 3.8 (0–30.7) |
| Sex | |
| Male | 16 (43.2) |
| Female | 21 (56.8) |
| Histology | |
| Papillary | 32 (86.5) |
| Follicular | 3 (8.1) |
| Poorly differentiated | 2 (5.4) |
| Performance status | |
| ECOG 0–1 | 16 (43.2) |
| ECOG 2 | 14 (37.8) |
| ECOG 3 | 7 (18.9) |
| Symptoms | |
| Sensory deficit | 1 (2.7) |
| Motor deficit | 8 (21.6) |
| Headache | 4 (10.8) |
| Nausea/vomiting | 2 (5.4) |
| Mental change | 3 (8.1) |
| Ataxia | 2 (5.4) |
| Dizziness | 4 (10.8) |
| Memory loss | 1 (2.7) |
| None | 12 (32.4) |
| Number of BM sites | |
| 1–3 | 21 (56.8) |
| 4–9 | 11 (29.7) |
| ≥ 10 | 5 (13.5) |
| Site of initial distant metastasis | |
| Lung | 25 (67.6) |
| Brain | 13 (35.1) |
| Lymph node | 2 (5.4) |
| Bone | 4 (10.8) |
| Spine | 5 (13.5) |
| Other | 3 (8.1) |