Table 1. Maternal Risk Factors and pregnancy characteristics.
| Maternal risk factors | Any SSRI (n = 358) (n) % | No SSRI (n = 24 402) (n) % | p-value |
|---|---|---|---|
| Age (y)>35 | (58) 16 | (3338) 13.7 | 0.012 |
| <18 | (1) 0.3 | (149) 0.6 | 0.641 |
| Pregravid BMI > 26 kg/m2 | (118) 34 | (6537) 28.2 | 0.012 |
| Smoking (>5 cigarettes /day) | (48) 13.4 | (1003) 4.1 | <0.00012 |
| Pregravid alcohol consumption (yes) | (126) 36.7 | (9479) 40.7 | 0.082 |
| Alcohol consumption during pregnancy (yes) | (10) 2.9 | (137) 0.6 | <0.0001 |
| Chronic illness (yes)3 | (63) 17.6 | (3403) 13.9 | 0.032 |
| Diabetes (yes) | (3) 0.8 | (223) 0.9 | 1.002 |
| Hypertension (yes) | (8) 2.2 | (502) 2.1 | 0.551 |
| Low haemoglobin (<120 g/l) | (12) 3.4 | (670) 2.7 | 0.481 |
| Nulliparity (yes) | (116) 32.4 | (9955) 40.8 | 0.0012 |
| Prior termination (yes) | (62) 17.3 | (3042) 12.5 | 0.0071 |
| Prior caesarean section (yes) | (35) 9.8 | (1785) 7.3 | 0.081 |
| Prior miscarriage (yes) | (95) 26.5 | (4839) 19.8 | 0.0021 |
1 χ2 test
2 Fisher’s exact test
BMI = body mass index
3Arterial hypertension, rheumatoid arthritis and other systemic connective tissue diseases, heart defects, asthma, kidney diseases, epilepsy and thyroid diseases
Information lacking from the data: breech presentation (n = 734), velamentous umbilical cord insertion (n = 740)