Algorithm 3.
1. Obtain gene specific p-values. |
2. Estimate the gene network using the PNS algorithm (Algorithm 1). |
3. Incorporate the information from steps 1 and 2 into the HMRF model and estimate the parameters of the HMRF model (Algorithm 2). |
4. Apply the Bayesian FDR correction to determine the risk genes [equation (3.5)]. |