Fig. 5.

The development of mechanical allodynia at the level of a T12 spinal cord injury site. Testing sessions consisted of 10 stimulations with an innocuous, monofilament stimulus 1 week before injury and at 2, 3, and 4 weeks after injury. Each data point represents the mean±SEM number of avoidance responses made to 10 stimulations. The number of avoidances made in response to dorsal trunk stimulation was significantly reduced after anti-CD11d mAb treatment (filled squares) (n=7) when compared with vehicle-treated animals (open squares) (n=8), suggesting the reduction of at-level mechanical allodynia. *, P<0.05 compared with vehicle-treated rats; +, P<0.05 compared with mean responses before injury.

Adapted, with permission, from Oatway et al. (2005)