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. 2016 Apr 29;5:16. doi: 10.1186/s40169-016-0095-4

Table 1.

Mitochondrial transplantation

Tissue Heart Heart Liver Brain
Animal model Rabbit Rabbit Rat Rat
Experimental model Langendorff perfused heart In situ, blood perfused In situ, blood perfused In situ brain
Injury model Ischemia/reperfusion Ischemia/reperfusion Ischemia/reperfusion Parkinson’s disease
Mitochondria Unmodified Unmodified Unmodified Conjugated with PEP-1
Delivery Direct injection Direct injection Direct injection Direct injection
Outcome Enhanced myocardial function following ischemia, enhanced cell viability Enhanced myocardial function following ischemia, enhanced cell viability Decreased liver tissue injury and apoptosis Peptide-mediated mitochondrial transplantation lessened Parkinson’s disease movement disorder and attenuated the deterioration of dopaminergic neurons
Reference McCully et al. [20] Masuzawa et al. [19] Lin et al. [51] Chang et al. [50]