Table II. p values for associations between ADHD and rare SNPs in the extended IPO11-HTR1A region.
| Genomic region | Positions (Build 37) |
SNP #
Total |
SNP #
(p<0.05) |
SNP #
(p<10−4) * |
SNP #
(q<0.05) |
Rare variant constellation | |
|---|---|---|---|---|---|---|---|
| p-value (T5) | p-value (Fp) | ||||||
| KIF2A | 61601989-61682210 | 48 | 5 | 0 | 0 | 0.374 | 0.378 |
| DIMT1L | 61684351-61699728 | 6 | 0 | 0 | 0 | 0.624 | 0.501 |
| DIMT1L × IPO11 | 61699729-61708572 | 7 | 1 | 0 | 0 | 0.509 | 0.238 |
|
Entire IPO11-HTR1A
region |
61708573-63257546 | 1143 | 64 | 2 | 1 | 8.0×10−31 | 1.3×10−32 |
| IPO11 | 61708573-61924416 | 94 | 6 | 0 | 0 | 3.6×10−10 | 3.2×10−10 |
| IPO11 × HTR1A | 61924417-63256278 | 1048 | 54 | 2 | 1 | 4.1×10−30 | 5.4×10−32 |
| “Significant region” | 62473343-63039074 | 585 | 17 | 2 | 1 | 4.0×10−17 | 1.1×10−17 |
| ISCA1P1 | 62071203-62073171 | 2 | 0 | 0 | 0 | 0.955 | 0.896 |
| TCONS_l2_00022340 | 62597333-62597863 | 0 | 0 | 0 | 0 | - | - |
| LOC100420027 | 62597350-62597883 | 1 | 0 | 0 | 0 | 0.606 | 0.606 |
| U5 snRNA | 62780084-62780130 | 0 | 0 | 0 | 0 | - | - |
| Y_RNA | 62855356-62855461 | 1 | 0 | 0 | 0 | 0.419 | 0.419 |
| TCONS_00010357 | 63179306-63183220 | 3 | 0 | 0 | 0 | 0.828 | 0.596 |
| HTR1A | 63256278-63257546 | 1 | 0 | 0 | 0 | 0.564 | 0.564 |
| HTR1A × RNF180 | 63257547-63461670 | 105 | 2 | 0 | 0 | 0.164 | 0.056 |
| RNF180 | 63461671-63668696 | 86 | 4 | 0 | 0 | 0.034 | 8.8×10−3 |
| RNF180 × RGS7BP | 63668697-63802451 | 65 | 0 | 0 | 0 | 0.112 | 0.065 |
| RGS7BP | 63802452-63908126 | 56 | 4 | 0 | 0 | 0.203 | 0.084 |
|
RGS7BP ×
SREK1IP1 |
63908127-64013974 | 81 | 3 | 0 | 0 | 0.579 | 0.245 |
| SREK1IP1 | 64013975-64064496 | 42 | 3 | 0 | 0 | 0.682 | 0.374 |
| CWC27 | 64064755-64314590 | 153 | 8 | 0 | 0 | 0.600 | 0.534 |
|
CWC27 ×
ADAMTS6 |
64314589-64444562 | 124 | 9 | 1 | 1 | 0.946 | 0.991 |
| ADAMTS6 | 64444563-64777704 | 225 | 20 | 0 | 0 | 0.403 | 0.325 |
|
ADAMTS6 ×
CENPK |
64777705-64813592 | 14 | 2 | 0 | 0 | 0.725 | 0.405 |
| CENPK | 64813593-64858995 | 26 | 1 | 0 | 0 | 0.577 | 0.530 |
| PPWD1 | 64859131-64883373 | 18 | 0 | 0 | 0 | 0.433 | 0.277 |
| TRIM23 | 64885507-64920187 | 17 | 1 | 0 | 0 | 0.333 | 0.185 |
| C5of44 | 64920558-64961954 | 24 | 3 | 0 | 0 | 0.206 | 0.202 |
| SGTB | 64961755-65017941 | 19 | 0 | 0 | 0 | 0.285 | 0.153 |
| NLN | 65018023-65125111 | 70 | 3 | 0 | 0 | 0.217 | 0.125 |
| NLN × ERBB2IP | 65125112-65222383 | 69 | 5 | 0 | 0 | 0.545 | 0.530 |
| ERBB2IP | 65222384-65376850 | 62 | 2 | 0 | 0 | 0.575 | 0.605 |
| Total | 61601989-65376850 | 2460 | 140 | 3 | 2 | ||
T5 and Fp, association tests using SCORE-Seq. x, intergenic region between two genes; ISCA1P1 and LOC100420027, pseudo gene loci; TCONS_l2_00022340 and TCONS_00010357, long non-coding RNAs. “Significant region”, a significant risk region for alcohol and nicotine co-dependence reported previously.
*
details are shown in Table III.